Perspective Therapeutics, Inc. (CATX) · Nov 6, 2026 · Other events

Perspective Therapeutics trial data sharpens Phase 3 path

GEP-NET enrichment — 75% PFS at 18 months; 39% ORR in 57 SSTR2-positive GEP-NET patients

Perspective Therapeutics’ trial data strengthens the case for an SSTR2-selected GEP-NET registration study, but remains an early, retrospective subgroup readout.

Perspective is a clinical-stage radiopharmaceutical company trying to move its targeted alpha therapy bamzireotide from dose-finding into a registration-enabling program. The October 23, 2026 ESMO update had already established the broad story: durable disease control, response rates of 33% and 50% in Cohorts 2 and 3, and a planned path toward Phase 3 site preparation.

The new information is not that bamzireotide works, but where it appears to work best. In the retrospective subgroup of 57 GEP-NET patients whose target lesions all expressed SSTR2, 18-month progression-free survival was 75%, while disease control reached 92% in Cohort 2 and 100% in Cohort 3. 〔0〕

Metric (source)	NANETS 2026	Comparison
ORR, SSTR2-positive GEP-NETs (Efficacy table)	39%	13% approved radiotherapy
PFS at 18 months, SSTR2-positive GEP-NETs (Efficacy table)	75%	~65% approved radiotherapy
Disease control, Cohort 2 (Efficacy table)	92%	89% all treated patients
Disease control, Cohort 3 (Efficacy table)	100%	95% all treated patients

That sharpens the development strategy, rather than proving a new efficacy step-change. The company is now considering an enrichment strategy that would focus a future registration study on GEP-NET patients with SSTR2 expression in every target lesion. That is a meaningful improvement in trial design and regulatory positioning, but it is based on a small, retrospective subgroup, and the headline response figures include some unconfirmed responses. 〔1〕

Safety remains supportive and does not add a new obstacle. Across 68 treated patients, there were no dose-limiting toxicities, treatment-related discontinuations, or serious adverse events related to study medication during the treatment-emergent window; however, long-term renal follow-up is still ongoing. 〔2〕

The regulatory timeline is more concrete, but still conditional. Perspective is targeting an end-of-Phase 2 FDA meeting in the first quarter of 2027 and expects a Phase 3 start in 2027 if FDA feedback and the remaining clinical, regulatory, and operational work align. The company's cash position had previously been described as sufficient for planned milestones into late 2027, so this update advances the program without immediately creating a disclosed financing requirement. 〔3〕

Bottom line: This is a modestly positive refinement of an already favorable clinical story: the strongest signal is becoming narrower and more actionable, but it remains an early subgroup analysis awaiting regulatory validation and prospective confirmation.

What to watch next

End-of-Phase 2 FDA meeting, first quarter 2027

Original filing on SEC EDGAR

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QNX revenue +27% to $80.3M; segment EBITDA $29.0M from $20.5M. “Record performance… core automotive.”Segment — QNX
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FY27 guide lifted to $616–636M rev / $141–158M EBITDA, above the prior $594–621M / $119–139M framework.Guidance
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Events/ANDE/8-K · Earnings

8-K · Item 2.02 · Earnings

The Andersons — a record Renewables quarter that beat profit expectations

Filed Aug 3, 2026ANDE · NASDAQ

AllSight readBeatPriced in▲ 1.8% since filed · reaction agrees

adj. EPS $2.15 vs ~$1.48 consensus

This filing tests whether The Andersons' sharp profit increase reflects broad operating improvement or a one-off renewable-fuels boost. It also separates strong adjusted earnings and cash generation from the quarter's legal and impairment charges.

The quarter was substantially stronger than both last year and the published earnings expectation. Adjusted EPS reached $2.15, versus $0.24 a year earlier and above the published consensus of about $1.48; reported EPS was $1.65. Adjusted EBITDA more than doubled to $140 million, while sales slipped modestly — the improvement came from margins and operating performance rather than higher revenue. Financial Highlights · Statements of Operations

Q2 ($M, exc. per-share)	Q2 2026	Q2 2025	YoY
Sales & merchandising revenue	3,097.7	3,135.9	−1%
Net income (attributable)	56.6	7.9	+48.7
Diluted EPS	1.65	0.23	+1.42
Adjusted EPS	2.15	0.24	+1.91
Adjusted EBITDA	140.3	65.2	+75.1
Agribusiness adj. pretax	20.3	16.8	+3.5
Renewables adj. pretax	88.4	9.6	+78.8
Cash from operations	487.9	299.3	+188.6
Cash from ops (pre-WC)	112.9	42.9	+70.1

Renewables drove nearly all of the upside — the operating backdrop was strong, but the result also benefited materially from tax credits. Renewables' adjusted pretax income rose to $88 million on record production, stronger ethanol margins and merchandising gains. It also received $24 million of 45Z producer tax credits, so this was not solely a repeatable plant-margin improvement; the company did cite healthy export and domestic ethanol demand as supportive. Renewables — Record Q2 · Segment Data

Agribusiness improved, but it was a supporting contributor rather than the main earnings engine. Adjusted pretax income increased to $20 million as fertilizer margins improved and merchandising benefited from commodity-price volatility, despite lower fertilizer volumes. Agribusiness — Improved Q2 · Segment Data

Cash generation improved and funding capacity is comfortable, while reported earnings still absorbed meaningful non-core costs. Operating cash flow was $488 million ($113 million before working-capital changes); capital spending was $76 million. Adjusted EPS excludes $0.50 of legal-settlement, impairment and transaction items, so the $2.15 adjusted result runs ahead of the $1.65 reported. Leverage stays below the <2.5× debt-to-EBITDA target; no new quantified full-year outlook was given. Cash & Liquidity · Adjusted Net Income

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Perspective Therapeutics trial data sharpens Phase 3 path

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