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IONIS PHARMACEUTICALS INC (IONS)

IONIS PHARMACEUTICALS INC (IONS) stock — the fundamentals (P/E, market cap, valuation) and every material event, decoded in plain English.

IONIS PHARMACEUTICALS INC (IONS) stock — financials & valuation

Key numbers for IONIS PHARMACEUTICALS INC (IONS): P/E ratio, market cap, profit margins, returns, and whether the stock looks cheap or expensive versus its own 5-year range.

AllSight quality score: 33/100 — a percentile rank of IONIS PHARMACEUTICALS INC’s fundamentals against Manufacturing peers, weakest on growth. A quality ranking, not a price prediction.

Market cap$7.4B
P / S8.5×
EV / EBITDA-14.4×
Gross margin98.2%
Operating margin-68.0%
Net margin-64.7%
Return on equity-128.5%
ROIC-42.3%
Revenue growth-7.4%
Debt / equity3.0×
Dividend yield0.0%

Is IONIS PHARMACEUTICALS INC overvalued? P/S looks fair vs its 5-year range; P/B looks fair vs its 5-year range.

Independent of the events above — derived from IONIS PHARMACEUTICALS INC’s own financial statements and shown as context, never as advice.

Sep 23, 2026Above the bar
Ionis’ sefaxersen clears Phase 3 IgAN endpoint, but kidney-function proof still awaits
Sep 4, 2026FDA approval
Ionis wins early ZANVASTRO approval, but launch economics remain open
Sep 4, 2026Below the bar
Ionis pelacarsen fails Phase 3 heart-outcomes trial despite lowering Lp(a)
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